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The initial and significant event developed in ischemic stroke and other brain pathologies is the sudden decrease in blood flow and oxygen supply, leading to dysfunction of the mitochondria. We review a unique optical approach to evaluate brain mitochondrial function and microcirculatory blood flow, volume and oxygenation in real time in vivo. Four monitored physiological parameters are integrated into a new Brain Metabolic Score (BMS) calculated in real time and is correlated to Brain Oxygen Balance. The technology was used in experimental and clinical situations. Few models of brain monitoring during partial or complete ischemia were developed and used in naive animals or under brain activation protocols. It was found that mitochondrial function/dysfunction is the major and dominant parameter affecting the calculated Brain Metabolic Score. Using our monitoring system and suggested protocols will provide direct information regarding the ability of the tested brain to provide enough oxygen consumed by the mitochondria in the “resting” or in the “activated” brain in vivo and in real-time. Our studies indicated that testing the pathophysiology of the brain is a promising approach that may provide significant results to the R&D studies of ischemic stroke and other neuropathologies related to mitochondrial function.

Assessment of Brain Metabolic Score (BMS) In Vivo Based on Mitochondrial Activity in Neuropathology