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Background: Cardiovascular disease is a major complication of diabetes and early death among people with diabetes. MiR-126 and 210 expressions is altered in cardiac disease and causes heart failure. Methods: Animals divided into 5 groups as: control (Con), diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p, 35 mg/kg). Animals received crocin orally (50 mg/kg), voluntary exercise performed alone or together for 8 weeks. qRT–PCR method was used to determine the levels of miR-210 and miR-126 in cardiac tissue. Results: In comparison with non-treated group (p<0.001), the level of miR-210 and miR-126 in the cardiac tissue augmented in both crocin and voluntary exercise groups. Combination therapy with exercise and crocin magnified their effects on miR-210 and miR-126 levels (p<0.001). Also, MiR-210 levels were lower in crocin group than in exercise group (p<0.001). Discussion: Our data show that voluntary exercise combined with crocin through increasing miR-210 and miR-126 expression may provide a novel therapeutic plan for cardiovascular disease.

̒ulūm-i dārūyī

The Combination Effect of Voluntary Exercise and Crocin on Angiogenic miRNAs in High-Fat Diet/Low-Dose STZ-Induced Type2 Diabetes in Rats: miR-126 and miR-210