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Purpose:  To improve adipocytes differentiation &amp; glucose uptake activity of 3T3-L1 cells through sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), glucose transporter type 4 (GLUT-4) of (+)-catechin &amp; proanthocyanidin fraction Uncaria gambir Roxb.  Methods:  Adipocytes differentiation activity of (+)-Catechin of Uncaria gambir Roxb. was determined by oil red O staining method &amp; glucose uptake activity was determined by measuring 2-deoxyglucose uptake on 3T3-L1 cells. The ability of (+) - catechin as an activator of sirtuin-1 was assessed by administration of (+) - catechin with the presence of a specific inhibitor of sirtuin-1, nicotinamide. Metformin 1 mM &amp; 5 mM were used as positive control. Sirtuin-1, PPAR γ &amp; GLUT-4 expressions were determined by RT-PCR.  Results:  (+)-Catechin &amp; proanthocyanidin fraction of Uncaria gambir Roxb. were found to increase adipocyte differentiation &amp; glucose uptake by increasing activity of sirtuin-1 as well as metformin ( P ≤0.05). PPAR γ, GLUT-4 and sirtuin-1 expressions were known to be responsible for this activities.  Conclusion:  These results indicate that (+)-catechin &amp; proanthocyanidin fraction of Uncaria gambir Roxb. could be utilized as a renewable bioresource to develop potential antidiabetic and antiobesity agents.

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(+)-Catechin &amp; Proanthocyanidin Fraction of <i>Uncaria gambir</i> Roxb. Improve Adipocytes Differentiation &amp; Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions

(+)-Catechin & Proanthocyanidin Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions