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The megakaryocyte (Mg) numbers per cross-sectioned spleen slides were arbitrarily evaluated in untreated Balb/cann and C57Bl inbred mouse strains, in sublethally (600 R) and lethally (850 R) irradiated mice and in mice repopulated with syngeneic bone marrow or marrow stromal cell cultures at various time intervals. The impact of Mu-MSV infection or of Mu-MSV induced sarcoma on spleen Mg was also evaluated. Spleens of control mice of both strains harbored numerous Mg. Following sublethal irradiation, severe atrophy of the spleen resulted in the disappearance of Mg from day 6 lasting to day 16. Repopulation with marrow cells lead to the reappearance of Mg by day 8, their proliferation as evidenced by mitosis and full recovery of the population on day 24. Bone marrow stromal cell cultures failed to repopulate irradiated spleens with Mg. C57Bl mice irradiated with 850 R and repopulated with syngeneic bone marrow also recovered their Mg population, although a full recovery required a longer time. Mg in the spleen of Moloney sarcoma virus infected mice or in spleen of mice which developed tumours following local administration of Mu-MSV greatly increased in number by day 18 post infection, and their numbers exceeded those of normal animals, thus the Mu-MSV can be considered as having a positive effect on spleen Mg in rodents.

folia biologica

Repopulation of Irradiated Mice with Medicinally Stimulating Cells and Infection with Moloney Sarcoma Virus Have a Profound Effect on Regeneration of Splenic Megakaryocytes