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The aim of the study was to determine the effect of a single dose of flunixin meglumine on serum interleukine-1â and serum and seminal plasma testosterone given at various times after the administration of endotoxin in stallions. Four healthy stallions were infused with endotoxin (LPS) from Escherichia coli 055:B5 in doses of 0.3 ìg/kg b.w. (group ENDO). Eight healthy stallions were treated with flunixin meglumine (1.1 mg/kg b.w., IV) 30 min (group ENDO+FM1, n=4), and 60 min (group ENDO+FM2, n=4) after the administration of LPS. Blood samples were obtained before infusion of LPS (marked as time 0) and 1, 2, 3, 4, 5, 6, 7, 8, 24, 48 and 72 hrs thereafter. In response to endotoxin infusion, the reaction of the stallions included fever (increased rectal temperature), increased heart rate, and leucopenia. Administration of endotoxin had an influence on the level of IL-1â (increase at 3-6 h after LPS administration) in the blood serum and testosterone in the blood serum (decrease at 3-24 h and increase at 48-72 h after LPS administration) and in seminal plasma (decrease at 24 h after LPS administration). Flunixin treatment prevented an endotoxin-induced increase in rectal temperature, heart rate, with no influence on the decrease of white blood cell numbers. Administration of flunixin meglumine (especially 60 min after LPS infusion) decreased the serum IL-1â level. FM (especially 30 minutes after LPS infusion) had a positive effect on the late changes of serum testosterone concentration after addition of endotoxin. Injection of FM (30 and 60 minutes after LPS administration) also had a positive effect on the seminal plasma T level of the stallions.

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Changes of Interleukin-1β and Testosterone Concentration after Nonsteroidal Anti-Inflammatory Drug Treatment at Different Times Relative to Endotoxin Administration in an Equine Model