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Background  Carbon tetrachloride (CCl 4 ) is a potent nephrotoxin, as it causes acute as well as chronic toxicity in kidneys. Therefore, this study was carried out to assess the pharmacological potential of different fractions of  Carissa opaca  fruits on CCl 4 -induced oxidative trauma in the kidney.    Methods  The parameters studied in this respect were the kidney function tests viz, serum profile, urine profile, genotoxicity, characteristic morphological findings, and antioxidant enzymatic level of kidneys.    Result  The protective effects of various fractions of  C. opaca  fruits against CCl 4  administration were reviewed by rat renal function alterations. Chronic toxicity caused by 8-week treatment of CCl 4  to the rats significantly decreased the pH level, activities of antioxidant enzymes, and glutathione contents, whereas a significant increase was found in the case of specific gravity, red blood cells, white blood cells, level of urea, and lipid peroxidation in comparison to control group. Administration of various fractions of  C. opaca  fruit with CCl 4  showed protective ability against CCl 4  intoxication by restoring the urine profile, activities of antioxidant enzymes, and lipid peroxidation in rat. CCl 4  induction in rats also caused DNA fragmentation and glomerular atrophy by means of dilation, disappearance of Bowmen's space, congestion in the capillary loops, dilation in renal tubules, and foamy look of epithelial cells of tubular region, which were restored by co-admiration of various fractions of  C. opaca .    Conclusion  Results revealed that the methanolic fractions of  C. opaca  are the most potent and helpful in kidney trauma.

Protective effects ofCarissa opacafruits against CCl4-induced oxidative kidney lipid peroxidation and trauma in rat

Protective effects ofCarissa opacafruits against CCl₄-induced oxidative kidney lipid peroxidation and trauma in rat