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Background  COVID-19 cases were first detected in the UK in January 2020 and vulnerable patients were asked to shield from March to reduce their risk of COVID-19 infection.    Aim  To determine the risk and determinants of COVID-19 diagnosis in shielded versus non-shielded groups, adjusted for key comorbidities not explained by shielding.    Design &amp; setting  Retrospective cohort study of adults with COVID-19 infection between 1 February 2020 and 15 May 2020 in west London.    Method  Individuals diagnosed with COVID-19 were identified in SystmOne records using clinical codes. Infection risks were adjusted for sociodemographic factors, nursing home status, and comorbidities.    Results  Of 57 713 adults, 573 (1%) individuals were identified as shielded and 1074 adults had documented COVID-19 infections (1.9%). COVID-19 infection rate in the shielded group individuals compared with non-shielded adult individuals was 6.5% ( n  = 37/573) versus 1.8% ( n  = 1037/57 140),  P  30 kg/m 2 ) (aHR 1.39; 95% CI = 1.18 to 1.63;  P &lt;0.001); and age (aHR 1.02; 95% CI = 1.01 to 1.02;  P &lt;0.001. Male sex was associated with lower risk of COVID-19 infection (aHR 0.71; 95% CI = 0.62 to 0.82;  P &lt;0.001).    Conclusion  Shielded individuals had a higher COVID-19 infection rate compared with non-shielded individuals, after adjusting for sociodemographic factors, nursing home status, and comorbidities.

Risk of COVID-19 in shielded and nursing care home patients: a cohort study in general practice