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A rapid, simple, selective and precise UVVisible Spectrophotometric method has been developed for the determination of metformin hydrochloride in bulk forms and tablet dosage formulations. The spectrophotometric detection was as per carried out at an absorption maximum of 232 nm using phosphate buffer of pH 6.8 as solvent. The method was validated for specificity, linearity, accuracy, precision, robustness and ruggedness. The detector response for was linear over the selected concentration range 2 to 12μg/ml with a correlation coefficient of 0.994. The accuracy was carried out as per recovery study and found between 99.1 % to 100.45%. The results demonstrated that the excipients in the tablets did not interfere with the method and can be conveniently employed for routine quality control analysis of metformin in bulk and formulation.

Analytical Method Development and Validation for Estimation of Metformin in Bulk and Pharmaceutical Dosage Form by UV Spectrometric Method