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02 Introduction 03 Neuropatholical Findings in CTE 04 Background on Tau 08 Discussion 14 Clinical Relevance and Conclusions 17 Acknowledgements 18 Chapter 2: Elucidating the role of compression waves and impact duration for generating mild traumatic brain injury in rats Abstract 26 Introduction 27 Methods 28 Results 33 Discussion 38 Acknowledgements 40 Chapter 3: The quest to model chronic traumatic encephalopathy: A multiple model & injury paradigm experience 26 Introduction 27 Methods 28 Results 33 Discussion 38 Acknowledgements 40 Chapter 3: The quest to model chronic traumatic encephalopathy: A multiple model & injury paradigm experience Abstract 50 Introduction 51 Methods 53 Results 58 Discussion 65 Acknowledgements 68 Chapter 4: Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury Abstract 82 50 Introduction 51 Methods 53 Results 58 Discussion 65 Acknowledgements 68 Chapter 4: Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury Abstract 82

Elucidating and Pharmacologically Targeting Secondary Injury Cascades following Neural Injury