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Identification and characterization of the E(var)3-5 gene in Drosophila melanogaster Pranoti Sahasrabhojane The goals of my research project were to clone the E(var)3-5 gene and characterize the lethality of E(var)3-5 mutations. The E(var)3-5 gene was identified by dominant mutations that enhanced PEV of w, thus implicating the gene product in promoting a euchromatic chromatin structure (Dorn et al. 1993). These mutations were found to be recessive lethal as well and the lethal phenotype was used to map the E(var)3-5 gene (Dorn et al. 1993; this work). I characterized the lethality of E(var)3-5 mutations and found that lethality in E(var)3-5 hemizygotes is manifested at the pupal stage. I mapped the lethality to a region defined by Df(3R)Exel7310. I generated five FLP-FRT mediated deletions within the region defined by Df(3R)Exel7310 however, my complementation analysis revealed that E(var)3-5 mutants were not allelic to any of the genes in that region. However I identified a mutation in one of the genes, CG17360 in all E(var)3-5 mutants examined. The CG17360 mutants exhibit an unexpanded wing phenotype.