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II Dedication  IV Acknowledgements  V Abbreviations  VI TABLE OF CONTENTS  VIII Architecture of the Bone Marrow Microenvironment: Hematopoesis & Normal B-Cell Development  1 I. Physical Structure of the Niche  2 II. Characteristics of a hematopoietic stem cell (HSC)  7 III. Normal B cell development.  9 IV. Damage to the microenvironment alters support of stem and progenitor cells.. .... 12 Reference List 16 Critical Components of a Functional Stem Cell Niche are Damaged by Chemotherapy  33 Abstract  34 34 Introduction  35 Materials and Methods  38 Results  43 Discussion  47 Figure Legends  53

VE-Cadherin Expression and Regulation of Sensitivity to Apoptosis in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia