English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

EVALUATION OF MATERNAL SERUM TRIPLE SCREEN AS AN IDENTIFIER OF TRISOMY 21 PREGNANCY Jonnie A. Lane Maternal serum triple screen is used to identify women under 35 years of age who are at an increased risk of having a fetus with Down syndrome. The screen identifies 5% of all women tested as being at an increased risk but only 2-3% of these women actually have a fetus with chromosome abnormalities, indicating a high false positive rate. Preliminary evaluation of 300 cases indicated that the number of trisomic fetuses identified by maternal serum triple screen in our population was considerably lower than expected. Medical records for 900 cases referred for maternal serum triple screen and maternal age were reviewed for maternal age, individual risk of carrying a fetus with Down syndrome, karyotype results and ultrasound abnormalities. Among the maternal serum screen group, 0.77% had an abnormal karyotype and among the maternal age group, 1.2% had an abnormal karyotype. These percentages of abnormal karyotypes are not significantly different from each other or the expected value. Statistical comparisons of risk figures between the two populations indicate that they are also not significantly different. While 3% of all cases with normal karyotypes had ultrasounds with one or more abnormalities, 33% of cases with abnormal karyotypes had an abnormal ultrasound. The data suggest that ultrasound may be helpful in identifying fetuses with Down syndrome. While maintaining the same detection rate of Down syndrome fetuses it would also decrease the number of invasive procedures performed.

Evaluation of maternal serum triple screen as an identifier of trisomy 21 pregnancy