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Although water transfer projects can alleviate the water crisis, they may cause potential risks to water quality safety in receiving areas. The Miyun Reservoir in northern China, one of the receiving reservoirs of the world’s largest water transfer project (South-to-North Water Transfer Project, SNWTP), was selected as a case study. Considering its potential eutrophication trend, two machine learning models, i.e., the support vector machine (SVM) model and the random forest (RF) model, were built to investigate the trophic state by predicting the variations of chlorophyll-a (Chl-a) concentrations, the typical reflection of eutrophication, in the reservoir after the implementation of SNWTP. The results showed that compared with the SVM model, the RF model had higher prediction accuracy and more robust prediction ability with abnormal data, and was thus more suitable for predicting Chl-a concentration variations in the receiving reservoir. Additionally, short-term water transfer would not cause significant variations of Chl-a concentrations. After the project implementation, the impact of transferred water on the water quality of the receiving reservoir would have gradually increased. After a 10-year implementation, transferred water would cause a significant decline in the receiving reservoir’s water quality, and Chl-a concentrations would increase, especially from July to August. This led to a potential risk of trophic state change in the Miyun Reservoir and required further attention from managers. This study can provide prediction techniques and advice on water quality security management associated with eutrophication risks resulting from water transfer projects.

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Machine Learning-Based Prediction of Chlorophyll-a Variations in Receiving Reservoir of World’s Largest Water Transfer Project—A Case Study in the Miyun Reservoir, North China