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Extended-spectrum beta-lactamase (ESBL) producing bacteria of the Enterobacteriaceae family are a significant threat to public health, posing a challenge for health authorities worldwide. In the UAE, very little information is available about ESBL producing bacteria from non-clinical sources. In this study, 206 pure cultures belonging to the Enterobacteriaceae family were isolated from food and wastewater sources in Dubai, UAE. All the isolates were tested against third-generation cephalosporin antibiotics by the disc diffusion method and screened on ESBL chromogenic agar. Among all isolates (n = 86), 41.7% were potential ESBL producers belonging to E. coli, Klebsiella, Enterobacter, Shigella, and Citrobacter (KESC group), and Proteus. Of all the potential ESBL producing isolates, 19 (22%) were confirmed as ESBL producers by a double-disc diffusion test with the fourth generation cephalosporin–Cefpirome. The multiplex polymerase chain reaction was used for the detection of ESBL bla genes in the screened isolates. Out of a total of 86 isolates, 52.3% possessed only the blaTEM gene; 39.5% contained both blaTEM and blaSHV genes, while only 3.5% contained the blaCTX-M gene. The carbapenemase resistance test showed eight isolates resistant to imipenem, and only one isolate with metallo-beta-lactamase activity. This study highlights the occurrence of ESBL bla genes among non-clinical isolates from food and wastewater sources in the UAE and emphasizes the importance of food and wastewater surveillance programs in controlling the spread of antibiotic resistance.

Occurrence of Extended Spectrum Beta-Lactamase Gram-Negative Bacteria from Non-Clinical Sources in Dubai, United Arab Emirates