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Single-cell ATAC-seq (scATAC-seq), as the updating of ATAC-seq, provides a novel method for probing open chromatin sites. Currently, research of scATAC-seq is faced with the problem of high dimensionality and the inherent sparsity of the generated data. Recently, several works proposed the use of an autoencoder–decoder, a symmetry neural network architecture, and non-negative matrix factorization methods to characterize the high-dimensional data. To evaluate the performance of multiple methods, in this work, we performed a multiple comparison for characterizing scATAC-seq based on four kinds of auto-encoders known as a symmetry neural network, and two kinds of matrix factorization methods. Different sizes of latent features were used to generate the UMAP plots and for further K-means clustering. Using a gold-standard data set, we practically explored the performance among the methods and the number of latent features in a comprehensive way. Finally, we briefly discuss the underlying difficulties and future directions for scATAC-seq characterizing. As a result, the method designed for handling the sparsity outperforms other tools in the generated dataset.

A Multiple Comprehensive Analysis of scATAC-seq Based on Auto-Encoder and Matrix Decomposition