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In this paper, firstly the definitions of the families of three-variable polynomials with the new generalized polynomials related to the generating functions of the famous polynomials and numbers in literature are given. Then, the explicit representation and partial differential equations for new polynomials are derived. The special cases of our polynomials are given in tables. In the last section, the interesting applications of these polynomials are found.

New Families of Three-Variable Polynomials Coupled with Well-Known Polynomials and Numbers