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Sustainability is conceptualized, approached and acted upon differently by people, sectors, societies, nations and educational systems. Consequently, the “sustainability thinking”-related scientific, technological, environmental, societal, economic and policy/political components are expected to transform differently. The related necessary transformative paradigm shifts in science, technology, environment, society, economy and policy (STESEP)—education from the contemporary disciplinary science, technology and environmental teaching to “know”—to transdisciplinary learning to “think” are to be expected. The overriding purpose: ensuring “sustainability thinking” by responsible, capable “STESEP literate” citizens. Consequently, “sustainability thinking” in the STESEP interfaces contexts, requires (1) the development of students’ higher-order cognitive skills (HOCS) via a transformative/transdisciplinary “STESEP Education”; (2) a research-based shift from the conventional algorithmic lower-order cognitive skills (LOCS)-based teaching to “know”, to “HOCS learning” to “think”; and (3) a special focus on HOCS-promoting teaching, assessment and learning strategies in science, technology, engineering, mathematics, environment, society and education. A pre-post research design of system thinking, evaluative thinking, and decision making capabilities of 10 grade high school, undergraduate and graduate students, in Israel, are presented and discussed in the learning for “sustainability thinking” context. In conclusion: contemporary science education in secondary and tertiary levels is mainly, disciplinary (biology, chemistry, mathematics, physics) in science, technology and engineering courses. The LOCS-to-HOCS  paradigm shift still constitutes a major issue of concern, with respect to ensuring a transformative science/STESEP education, targeting “sustainability thinking” in secondary and tertiary education

Research-Based Transformative Science/STEM/STES/STESEP Education for “Sustainability Thinking”: From Teaching to “Know” to Learning to “Think”