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(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7TMagnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500MBq    , enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of54.2mmand an inner diameter of 114mm    . It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between(  209.0  ±  0.3  )psand(  12.41  ±  0.02  )  %Full Width at Half Maximum (FWHM) at low activity and(  326.89  ±  0.12  )psand(  20.630  ±  0.011  )  %FWHM at 550MBq    , respectively. The peak sensitivity is ∼1.6  %. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300MBq    . Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2mmin the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500MBq    .

SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI