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The spread of antimicrobial resistance calls for chronic wound managementdevices that can engage with the wound exudate and signal infection by promptvisual effects. Here, the manufacture of a two-layer fibrous device withindependently-controlled exudate management capability and visual infectionresponsivity was investigated by sequential free surface electrospinning ofpoly(methyl methacrylate-co-methacrylic acid) (PMMA-co-MAA) and poly(acrylicacid) (PAA). By selecting wound pH as infection indicator, PMMA-co-MAA fibreswere encapsulated with halochromic bromothymol blue (BTB) to trigger colourchanges at infection-induced alkaline pH. Likewise, the exudate managementcapability was integrated via the synthesis of a thermally-crosslinked networkin electrospun PAA layer. PMMA-co-MAA fibres revealed high BTB loadingefficiency (> 80 wt.%) and demonstrated prompt colour change and selective dyerelease at infected-like media (pH > 7). The synthesis of thethermally-crosslinked PAA network successfully enabled high water uptake (up tonearly 2500 wt.%) and swelling index (up to nearly 300 a.%), in contrast toelectrospun PAA controls. This dual device functionality was lost when the samebuilding blocks were configured in a single-layer mesh of core-shell fibres,whereby significant BTB release (~ 70 wt.%) was measured even at acidic pH.This study therefore demonstrates how the fibrous configuration can beconveniently manipulated to trigger structure-induced functionalities criticalto chronic wound management and monitoring.

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response