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In this work the highly sensitive molecule recognition performance of a specially designed surface enhanced Raman scattering (SERS) substrate was demonstrated. The general inverse pyramid structures were modified to be able to perform as cavities in perforated membrane applicable for particle and cell filtering, sorting and trapping. In the voids of the gold covered substrate size compatible particles functionalised by different molecules were trapped, their SERS signal was detected and the different molecules were recognised.

SERS Active Periodic 3D Structure for Trapping and High Sensitive Molecular Analysis of Particles or Cells