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Oral mucositis (OM) is the oral inflammation as manifestation of chemotherapy and/or radiotherapy. Cinnamomum osmophloeum (CO), of which the constituents possess anti-inflammatory activities, may have potential to alleviate OM. In this study, laboratory rats were injected with 5-Fluororacil and their oral mucosa were irritated by 18-gauge needle pouching to induce OM. Rats were randomly divided into six experimental groups: without treatment (WT), only 100 mg/mL CO leaf extract (COLE) treatment (100-only), only 5-Fluororacil treatment (5-FU), 5-FU then treated with Triamcinolone acetonide orobase (5-FU+G), 5-FU then treated with 50 mg/mL COLE, and 5-FU then treated with 100 mg/mL COLE (5-FU+100). Body weights and food and water intakes during the experimental period were recorded. Macroscopic examination, histopathological analyses, and serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels of these rats were evaluated or determined. No significant difference was found between the WT and 100-only groups. Results of macroscopic examinations, histopathological analyses, body weight changes, food and water intakes, and serum IL-1β and IL-6 levels showed significant therapeutic effects of the 5-FU+100 group compared to the 5-FU group. These finding suggest that COLE can be one of potential remedies for OM therapy through influencing proinflammatory cytokine levels.

Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1β and IL-6 Levels