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Removal of biofilms is extremely pivotal in environmental and medicinal fields. Therefore, reporting the new-enzymes and their combinations for dispersal of infectious biofilms can be extremely critical. Herein, for the first time, we accessed the enzyme "protease from bovine pancreas type-I (PtI)" for anti-biofilm properties. We further investigated the anti-biofilm potential of PtI in combination with α-amylase from Bacillus sp . (αA). PtI showed a very significant biofilm inhibition effect (86.5%, 88.4%, and 67%) and biofilm prevention effect (66%, 64%, and 70%), against the E. coli , S. aureus , and MRSA, respectively. However, the new enzyme combination ( Ec -PtI+αA) exhibited biofilm inhibition effect (78%, 90%, and 93%) and a biofilm prevention effect (44%, 51%, and 77%) against E. coli , S. aureus , and MRSA, respectively. The studied enzymes were found not to be anti-bacterial against the E. coli , S. aureus , and MRSA. In summary, the PtI exhibited significant anti-biofilm effects against S. aureus , MRSA, and E. coli . Ec -PtI+αA exhibited enhancement of the anti-biofilm effects against S. aureus and MRSA biofilms. Therefore, this study revealed that this Ec -PtI+αA enzymatic system can be extremely vital for the treatment of biofilm complications resulting from E. coli , S. aureus , and MRSA.

Efficient Biofilms Eradication by Enzymatic-Cocktail of Pancreatic Protease Type-I and Bacterial α-Amylase