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Four new eudesmane-type sesquiterpenoids, (1 R ,5 S ,6 R ,7 S ,9 S ,10 S )-1,6,9-trihydroxy-eudesm-3-ene-1,6-di- O - β -d-glucopyranoside ( 1 ), (1 R ,5 S ,6S,7 R ,9 S ,10 S )-1,6,9,11-tetrahydroxy-eudesm-3-ene-1,6-di- O - β -d-glucopyranoside ( 3 ), (1 R ,5 S ,6 R ,7 S ,9 S ,10 R )-9- O -( Z - p -coumaroyl)-1,6,9-trihydroxy-eudesm-3-ene-6- O - β -d-glucopyranoside ( 6 ), and (1 R ,5 S ,6 R ,7 S ,9 S ,10 R )-9- O -( E -feruloyl)-1,6,9-trihydroxy-eudesm-3-ene-6- O - β -d-glucopyranoside ( 7 ), were isolated from a 95% EtOH extract of the leaves of Aster koraiensis by repeated chromatography. Moreover, three sesquiterpenoids ( 2 , 4 , and 5 ) and two caffeoylquinic acids ( 8 and 9 ) having previously known chemical structures were isolated during the isolation procedure. The four new compounds ( 1 , 3 , 6 , and 7 ) were elucidated by spectroscopic data (1D- and 2D-NMR, MS, and ECD) interpretation and hydrolysis. Moreover, the absolute configurations of 2 , 4 , and 5 were determined for the first time in this study. The compounds isolated were tested for their viability on nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) production on LPS-stimulated RAW 264.7 cells. Among them, only 7 presented weak inhibitory effects on both NO and PGE 2 production.

New Eudesmane-Type Sesquiterpene Glycosides from the Leaves of Aster koraiensis