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The aim of study was to validate, by in vitro and in vivo studies, the traditional use for wound-healing activity of  Artemisia absinthium  L. Reversed-phase liquid chromatography coupled with diode array detection and electrospray ion trap mass spectrometry (RP-LC-DAD-ESI-MS) analysis allowed to identify eleven polyphenols with chlorogenic acid as the most abundant compound (3.75 g/100 g of dry extract). After that, antibacterial activity as well as acute dermal and oral toxicity were assessed in animal models. In order to investigate the wound-healing activity of  A. absinthium  methanol extract, two ointments were formulated (MEO 5% and 10%). The ointment with the highest concentration of plant extract (10%) showed a statistically significant effect on the rats wound contraction, similar to that exerted by the reference drug Cicatryl-Bio. Moreover,  A. absinthium  methanol extract showed the best antibacterial activity against the Gram-negative  Escherichia coli  ATCC 10536 (MIC 1.25–2.5 mg/mL) and the Gram-positive  Staphylococcus aureus  ATCC 6538 (0.31–0.625 mg/mL). The absence of oral and topical toxicity of the treated animals allowed to establish the safety of the ointments. Overall, data collected in the present study support and validate the use of  A. absinthium  as a wound healing agent in the Algerian traditional medicine.

Phytochemical Profile, Safety Assessment and Wound Healing Activity of Artemisia absinthium L.