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The present study aimed to determine the antimicrobial activity and chemical composition of leaves-extracted essential oil of  Leoheo domatiophorus  Chaowasku, D.T. Ngo and H.T. Le ( L. domatiophorus) , including antibacterial, antimycotic, antitrichomonas and antiviral effects. The essential oil was obtained using hydrodistillation, with an average yield of 0.34 ± 0.01% ( v/w , dry leaves). There were 52 constituents as identified by GC/MS with available authentic standards, representing 96.74% of the entire leaves oil. The essential oil was comprised of three main components, namely viridiflorene (16.47%), (-)-δ-cadinene (15.58%) and γ-muurolene (8.00%). The oil showed good antimicrobial activities against several species: Gram-positive strains:  Staphylococcus aureus  (two strains) and  Enterococcus faecalis,  with Minimum Inhibitory Concentration (MIC) and Minimum Lethal Concentration (MLC) values from 0.25 to 1% ( v/v ); Gram-negative strains such as  Escherichia coli  (two strains),  Pseudomonas aeruginosa  (two strains) and  Klebsiella pneumoniae , with MIC and MLC values between 2% and 8% ( v/v ); and finally  Candida  species, having MIC and MLC between 0.12 and 4% ( v/v ).Antitrichomonas activity of the oil was also undertaken, showing IC 50 , IC 90  and MLC values of 0.008%, 0.016% and 0.03% ( v/v ), respectively, after 48h of incubation. The essential oil resultedin being completely ineffective against tested viruses, ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (hRSVA2, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses with EC 50  values over 100 µg/mL. This is the first, yet comprehensive, scientific report about the chemical composition and pharmacological properties of the essential oil in  L. domatiophorus .

In Vitro Antimicrobial Activity of Essential Oil Extracted from Leaves of Leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le in Vietnam