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Content of bioactive saponins of  Medicago  species suggests that they may also exert, as previously demonstrated on  M. sativa , nematicidal properties exploitable for the formulation of new products for sustainable phytoparasitic nematode management. This study was addressed to highlight the bioactivity of saponins from five different  Medicago  species still poorly known for their biological efficacy, i.e.,  M. heyniana, M. hybrida, M. lupulina ,  M. murex  and  M. truncatula , against the plant parasitic nematodes  Meloidogyne incognita ,  Xiphinema index  and  Globodera rostochiensis . The bioactivity of the extracts from the five  Medicago  species was assessed by in vitro assays on the juveniles ( J2 ) and eggs of  M. incognita  and  G. rostochiensis  and the adult females of  X. index . The suppressiveness to  M. incognita  of soil treatments with the  Medicago  plant biomasses was also investigated in a tomato experiment. The nematicidal activity of the five  Medicago  species was reported and discussed in relation to their phytochemical profile.

Activity of Saponins from Medicago Species against Phytoparasitic Nematodes