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Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of  Artemisia absinthium . In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus  Mucor plumbeus  affording the corresponding 1β, 10α-epoxide. A cadinane derivative was formed by an acid rearrangement produced in the culture medium, but not by the enzymatic system of the fungus. Furthermore, 3α-hydroxypelenolide showed strong antifeedant effects against  Leptinotarsa decemlineata  and cytotoxic activity to Sf9 insect cells ,  while the biotransformed compounds showed antifeedant postingestive effects against  Spodoptera littoralis.

Sesquiterpene Lactones from Artemisia absinthium. Biotransformation and Rearrangement of the Insect Antifeedant 3α-hydroxypelenolide