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Busulfan pharmacokinetics exhibit large inter-subject variability. Our objective was to evaluate the influence of glutathione S-transferase A1 ( GSTA1 ) gene variants on busulfan oral clearance (CLo) in a population of patients undergoing hematopoietic stem cell transplantation.

Impact of GSTA1 Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation