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Rotaviruses are a major etiologic agent of gastroenteritis in infants and young children worldwide. To learn the shift of genotypes and genetic characteristics of Rotavirus A (RVA) causing diarrhea in children and adults, a hospital-based surveillance of rotavirus was conducted in Wuhan, China from June 2011 through May 2019, and representative virus strains were phylogenetically analyzed. Among a total of 6733 stool specimens collected from both children and adults with acute gastroenteritis, RVA was detected in 25.5% (1125/4409) and 12.3% (285/2324) of specimens, respectively. G9P[ 8 ] was the most common genotype (74.5%), followed by G1P[ 8 ] (8.7%), G2P[ 4 ] (8.4%), and G3P[ 8 ] (7.3%), with G9P[ 8 ] increasing rapidly during the study period. The predominant genotype shifted from G1P[ 8 ] to G9P[ 8 ] in 2012-2013 epidemic season. G12P[ 6 ] strain RVA/Human-wt/CHN/Z2761/2019/G12P[ 6 ] was detected in April 2019 and assigned to G12-P[ 6 ]-I1-R1-C1-M1-A1-N1-T2-E1-H1 genotypes. Phylogenetic analysis revealed that VP7, VP4, VP6, VP3, NSP1, NSP2, and NSP5 genes of Z2761 clustered closely with those of Korean G12P[ 6 ] strain CAU_214, showing high nucleotide identities (98.0-98.8%). The NSP3 gene of Z2761 was closely related to those of G2P[ 4 ] and G12P[ 6 ] rotaviruses in Asia. All the eleven gene segments of Z2761 kept distance from those of cocirculating G9P[ 8 ], G1P[ 8 ], and G3P[ 8 ] strains detected in Wuhan during this study period. This is the first identification of G12 rotavirus in China. It is deduced that Z2761 is a reassortant having DS-1-like NSP3 gene in the background of G12P[ 6 ] rotavirus genetically close to CAU_214.

Surveillance of Human Rotavirus in Wuhan, China (2011–2019): Predominance of G9P[8] and Emergence of G12