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The Qinghai-Tibetan Plateau Area (QTPA) is a plateau with the highest average altitude, located in Northwestern China. There is a risk for interspecies disease transmission, such as spotted fever rickettsioses. However, information on the molecular characteristics of the spotted fever group (SFG)  Rickettsia  spp. in the area is limited. This study performed screenings, and detected the DNA of human pathogen, SFG  Rickettsia  spp., with 11.3% (25/222) infection rates in yaks ( Bos   grunniens ). BLASTn analysis revealed that the  Rickettsia  sequences obtained shared 94.3–100% identity with isolates of  Rickettsia  spp. from ticks in China. One  Rickettsia  sequence (MN536161) had 100% nucleotide identity to two  R. raoultii  isolates from Chinese  Homo sapiens , and one isolate from Qinghai  Dermacentor   silvarum . Meanwhile, another  Rickettsia  sequence (MN536157) shared 99.1–99.5% identity to one isolate from  Dermacentor  spp. in China. Furthermore, the phylogenetic analysis of SFG  Rickettsia  spp.  ompA  gene revealed that these two sequences obtained from yaks in the present study grouped with the  R. slovaca  and  R. raoultii  clades with isolates identified from  Dermacentor  spp. and  Homo sapiens . Our findings showed the first evidence of human pathogen DNA, SFG  Rickettsia  spp., from animals, in the QTPA.

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area