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Recently two peptides isolated from the Cuban freshwater snail  Pomacea poeyana  (Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability of  C. albicans ,  C. parapsilosis  and the less common species  C. auris  measured as the decrease of metabolic activity in the resazurin reduction assay for planktonic cells. Although these activities were low, Pom-1 and Pom-2 turned out to be highly potent inhibitors of biofilm formation for the three  Candida  species tested. Whereas Pom-1 was slightly more active against  C. albicans  and  C. parapsilosis  as representatives of the more common  Candida  species Pom-2 showed no preference and was fully active also against biofilms of the more uncommon species  C. auris . Pom-1 and Pom-2 may represent promising lead structures for the development of a classical peptide optimization strategy with the realistic aim to further increase antibiofilm properties and other pharmacologic parameters and to generate finally the first antifungal drug with a pronounced dedication against  Candida  biofilms.

Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candidaauris, C. parapsilosis and C. albicans Biofilms