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Cryptosporidium  felis  is an important cause of feline and human cryptosporidiosis. However, the transmission of this pathogen between humans and cats remains controversial, partially due to a lack of genetic characterization of isolates from cats. The present study was conducted to examine the genetic diversity of  C. felis  in cats in China and to assess their potential zoonotic transmission. A newly developed subtyping tool based on a sequence analysis of the 60-kDa glycoprotein ( gp60 ) gene was employed to identify the subtypes of 30 cat-derived  C. felis  isolates from Guangdong and Shanghai. Altogether, 20  C. felis  isolates were successfully subtyped. The results of the sequence alignment showed a high genetic diversity, with 13 novel subtypes and 2 known subtypes of the XIXa subtype family being identified. The known subtypes were previously detected in humans, while some of the subtypes formed well-supported subclusters with human-derived subtypes from other countries in a phylogenetic analysis of the  gp60  sequences. The results of this study confirmed the high genetic diversity of the XIXa subtype family of  C. felis . The common occurrence of this subtype family in both humans and cats suggests that there could be cross-species transmission of  C. felis .

Subtype Characterization and Zoonotic Potential of Cryptosporidium felis in Cats in Guangdong and Shanghai, China