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(1) Background: Whether early supplementation of probiotics to improve intestinal flora can effectively prevent eczema remains a controversial issue. We aimed to investigate the effect of a mixed strain of  Lactobacillus  and  Bifidobacterium  on eczema in infants under three years old at present; (2) Methods: We searched the databases of PubMed, Web of Science, and Cochrane Library, as well as National Knowledge Infrastructure (CNKI), WeiPu (VIP), and WanFang Data (WanFang) for randomized controlled trials (RCTs) of probiotics in the prevention of eczema in infants without language restriction. The main outcome was eczema incidence, while adverse events during the intervention constituted the secondary outcome. The random-/fixed-effects model was utilized to calculate the combined relative risk (RR) and 95% confidence interval (CI). The methodological quality of the study was evaluated using the Cochrane “bias risk” tool. According to the initial intervention time, subgroup analysis was carried out, follow-up time, family history, etc.; (3) Results: Nine articles were selected (2093 infants). The  Lactobacillus  and  Bifidobacterium  mixed strain could prevent eczema in infants under three years of age compared to the placebo (RR = 0.60; I 2  = 67%;  p  < 0.001). Subgroup analysis revealed that the mixture of two probiotic strains had preventive effects on both infants with positive (RR = 0.53; I 2  = 52%;  p  < 0.001) and negative (RR = 0.69; I 2  = 62%;  p  = 0.02) family history; The follow-up time for ≤12 months (RR = 0.65; I 2  = 12%;  p  = 0.01) and 12–24 months (RR = 0.60; I 2  = 79%;  p  = 0.003), daily dose of probiotics ≤ 1 × 10 9  and > 1 × 10 9  colony forming units all can be effective ( p  < 0.01); Compared with the intervention of infants alone (RR = 0.63; I 2  = 63%;  p  = 0.29), the effect of probiotics mixture at the beginning of pregnancy was more significant (RR = 0.59; I 2  = 71%;  p  < 0.001); Except for the mixture of  Lactobacillus rhamnosus   GG  ( LGG ) and  Bifidobacterium longum  ( B. longum ) ( p  = 0.18), other subgroups of intervention group can play a preventive effect ( p  < 0.05); (4) Conclusions: The mixed strain of  Lactobacillus  and  Bifidobacterium  can effectively reduce the incidence of eczema in infants under three years old. However, further research is needed to fully understand the exact mechanism of their effect on infant eczema.

Can Mixed Strains of Lactobacillus and Bifidobacterium Reduce Eczema in Infants under Three Years of Age? A Meta-Analysis