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New antibacterial treatments against  Helicobacter pylori  are needed as  H. pylori  is acquiring antibiotic resistance. β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication of  H. pylori  in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti- H.pylori  efficacy of β-caryophyllene, a total of 160 mice were divided into eight groups ( n  = 10 each) and were administered different treatments for 2 and 4 weeks.  H. pylori  eradication was assessed using a Campylobacter-like organism (CLO) test and  H. pylori  qPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively.  H. pylori  levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in  H. pylori -infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment of  H. pylori  infection.

Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model