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In this study, a fluorescence sensor based on nitrogen and phosphorus co-doped carbon dot/silver nanoparticle (NPCD/AgNP) nanocomposites was developed for metformin hydrochloride (MFH) detection. We first utilized the reducing nature of the NPCDs to prepare AgNPs from Ag+ and subsequently prepare NPCD/AgNP nanocomposites. The nanocomposite material was characterized by various methods, including electron microscopic methods (SEM and TEM), spectroscopic methods (UV-Vis, PL, FTIR, and XPS spectroscopy), light scattering (ELS), and XRD. Further, we utilized the enhanced fluorescence of the NPCDs as well as the overlap between the fluorescence emission spectrum of the NPCDs and the absorption spectrum of the AgNPs to use the NPCD/AgNP nanocomposites as an effective inner filter effect (IFE) pair for sensing MFH. The IFE between NPCDs and AgNPs in the nanocomposite material resulted in a significant quenching of the fluorescence intensity of the nanocomposites compared to that of the pure NPCDs. However, the fluorescence was recovered when MFH was introduced into the nanocomposite solution. The fluorescence intensity of the nanocomposites increased linearly as the MFH concentration increased from 2 to 100 µg/L. This detection method showed good sensitivity compared to other methods. It also showed high selectivity and high sensing potential for MFH in human serum and yielded acceptable results.

A Co-Doped Carbon Dot/Silver Nanoparticle Nanocomposite-Based Fluorescence Sensor for Metformin Hydrochloride Detection