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Materials based on calcium carbonate (CaCO 3 ) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO 3  and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO 3  (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug:  DOX orubicin ( DOX ). We also showed a prolonged pH-dependent release of  DOX  from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO 3 -and- DOX –based composite (CaNP 7 - DOX ) in in vitro models.

Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug