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Since the first introduction of one-dimensional nanochannels for single-molecule detection, there has been increasing interest in modern nanofluidic systems, such as chemical and biological sensing applications. Recently developed nanowires (NWs) and nanotubes (NTs) have received tremendous attention due to their unique geometrical, physical and chemical properties, which are very attractive in this field. Here, we review the recent research activities in the field of novel nanofluidic cells based on NWs and NTs. First, we give a brief introduction of this field. Then the common synthesis methods of NWs and NTs are summarized. After that, we discuss the working principle and sensing mechanism of nanofluidic devices, which is fundamental to the interaction between these nanostructures and small molecules. Finally, we present the NW- and NT-based devices for chemical and bio-sensing applications, such as gas sensing, pathogen detection, DNA sequencing, and so forth.

Novel Nanofluidic Cells Based on Nanowires and Nanotubes for Advanced Chemical and Bio-Sensing Applications