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In present work, carbon nanomaterials (CNMs) are investigated as potential carriers of 68 Ga, which is widely used in positron emission tomography (PET) in nuclear medicine. Sorption behavior of 68 Ga was studied onto CNMs of various structures and chemical compositions: nanodiamonds (ND), reduced graphite oxide (rGiO) and multi-walled carbon nanotubes (MWCNT), as well as their oxidized (ND-COOH) or reduced (rGiO-H, MWCNT-H) forms. The physicochemical properties of the nanoparticles were determined by high resolution transmission electron microscopy, x-ray photoelectron spectroscopy, dynamic light scattering and potentiometric titration. The content of 68 Ga in the solutions during the study of sorption was determined by gamma-ray spectrometry. The highest degree of 68 Ga sorption was observed on ND and ND-COOH samples, and the optimal sorption conditions were determined: an aqueous solution with a pH of 5-7, m/V ratio of 50 μg/mL and a room temperature (25 °C). The 68 Ga@ND and 68 Ga@ND-COOH conjugates were found to be stable in a model blood solution-phosphate-buffered saline with a pH of 7.3, containing 40 g/L of bovine serum albumin: 68 Ga desorption from these samples in 90 minutes was no more than 20% at 25 °С and up to 30% at 37 °С. Such a quantity of desorbed 68 Ga does not harm the body and does not interfere with the PET imaging process. Thus, ND and ND-COOH are promising CNMs for using as carriers of 68 Ga for PET diagnostics.

Carbon Nanomaterials for Sorption of 68Ga for Potential Using in Positron Emission Tomography