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Today,  44 Sc is an attractive radionuclide for molecular imaging with PET. In this work, we evaluated a  44 Ti/ 44 Sc radionuclide generator based on TEVA resin as a source of  44 Sc. The generator prototype (5 MBq) exhibits high  44 Ti retention and stable yield of  44 Sc (91 ± 6 %) in 1 mL of eluate (20 bed volumes, eluent—0.1 M oxalic acid/0.2 M HCl) during one year of monitoring (more than 120 elutions). The breakthrough of  44 Ti did not exceed 1.5 × 10 −5 % (average value was 6.5 × 10 −6 %). Post-processing of the eluate for further use in radiopharmaceutical synthesis was proposed. The post-processing procedure using a combination of Presep ®  PolyChelate and TK221 resins made it possible to obtain  44 Sc-radioconjugates with high labeling yield (≥95%) while using small precursor amounts (5 nmol). The proposed method takes no more than 15 min and provides ≥90% yield relative to the  44 Sc activity eluted from the generator. The labeling efficiency was demonstrated on the example of [ 44 Sc]Sc-PSMA-617 and [ 44 Sc]Sc-PSMA-I&T synthesis. Some superiority of PSMA-I&T over PSMA-617 in terms of  44 Sc labeling efficiency was demonstrated (likely due to presence of DOTAGA chelator in the precursor structure). It was also shown that microwave heating of the reaction mixture considerably shortened the reaction time and improved radiolabeling yield and reproducibility of [ 44 Sc]Sc-PSMA-617 and [ 44 Sc]Sc-PSMA-I&T synthesis.

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Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&amp;T Synthesis