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Glucosinolates (GSLs) from Lepidium graminifolium L. were analyzed qualitatively and quantitatively by their desulfo-counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products-isothiocyanates (ITCs) using GC-MS analysis. Thirteen GSLs were identified with arylaliphatic as the major ones in the following order: 3-hydroxybenzyl GSL (glucolepigramin, 7 ), benzyl GSL (glucotropaeolin, 9 ), 3,4,5-trimethoxybenzyl GSL ( 11 ), 3-methoxybenzyl GSL (glucolimnanthin, 12 ), 4-hydroxy-3,5-dimethoxybenzyl GSL (3,5-dimethoxysinalbin, 8 ), 4-hydroxybenzyl GSL (glucosinalbin, 6 ), 3,4-dimethoxybenzyl GSL ( 10 ) and 2-phenylethyl GSL (gluconasturtiin, 13 ). GSL breakdown products obtained by hydrodistillation (HD) and CH 2 Cl 2 extraction after hydrolysis by myrosinase for 24 h (EXT) as well as benzyl ITC were tested for their cytotoxic activity using MTT assay. Generally, EXT showed noticeable antiproliferative activity against human bladder cancer cell line UM-UC-3 and human glioblastoma cell line LN229, and can be considered as moderately active, while IC 50 of benzyl ITC was 12.3 μg/mL, which can be considered as highly active.

Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates