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A phytochemical investigation of the leaves of the medicinal plant Isodon rubescens led to the isolation of the two new degraded abietane lactone diterpenoids rubesanolides F ( 1 ) and G ( 2 ). Their structures were elucidated based on the analyses of the HRESIMS and 1D/2D NMR spectral data, and their absolute configurations were determined by ECD spectrum calculations and X-ray single crystal diffraction methods. Compounds 1 and 2 , with a unique γ-lactone subgroup between C-8 and C-20, were found to form a carbonyl carbon at C-13 by removal of the isopropyl group in an abietane diterpene skeleton. Rubesanolide G ( 2 ) is a rare case of abietane that possesses a cis -fused configuration between rings B and C. The two isolates were evaluated for their biological activities against two cancer cell lines (A549 and HL60), three fungal strains ( Candida alba , Aspergillus niger and Rhizopus nigricans ) and three bacterial strains ( Escherichia coli , Staphylococcus aureus and Bacillus subtilis ).

Rubesanolides F and G: Two Novel Lactone-Type Norditerpenoids from Isodon rubescens