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In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [ 99m TcN] 2+  core to obtain the  99m TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that  99m TcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that  99m TcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to  99m TcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of  99m TcN-CPF2XT were higher and the uptakes of  99m TcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that  99m TcN-CPF2XT would be a potential bacterial infection imaging agent.

Design, Preparation, and Evaluation of a Novel 99mTcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent