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Previously, various steroidal glycosides were reported from plants of Cestrum species. However, phytochemical investigation has not been conducted on Cestrum newellii . A systematic phytochemical investigation of the leaves of C. newellii resulted in the isolation of eight novel steroidal glycosides ( 1 - 8 ), which were classified into three spirostanol glycosides ( 1 - 3 ), two furostanol glycosides ( 4 and 5 ), two pseudofurostanol glycosides ( 6 and 7 ), and one cholestane glycoside ( 8 ). In addition, three known cholestane glycosides ( 9 - 11 ) were isolated and identified. The structures of the new compounds were determined based on spectroscopic data and chemical transformations. Compounds 1 and 2 are spirostanol glycosides having hydroxy groups at C-2, C-3, C-12, and C-24 of the aglycone moiety. Although C. newellii is known to be a poisonous plant, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H -tetrazolium bromide assay exhibited that none of the isolated compounds were cytotoxic to HL-60 human promyelocytic leukemia cells.

A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii