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Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol ® (modified Biolasol ® ), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se 4+ ions at a dose of 1 µg/L into the Biolasol ® preservation solution in the form of Na 2 SeO 3 caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se 4+ on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol ® modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO 3  2- ) during ischemia/reperfusion.

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation