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The anticancer and radiosensitizing effects of high-molecular-weight phlorethols CcPh (Mw = 2520 Da) isolated from the brown algae of Costaria costata on human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phlorethols CcPh possessed cytotoxic activity against HT-29 (IC 50 = 92 μg/mL) and HCT 116 (IC 50 = 94 μg/mL) cells. CcPh at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhanced their sensitivity to low non-toxic X-ray irradiation. The combinatory effect of radiation and CcPh was synergistic (Combination index &lt; 0.7). Algal phlorethols might be prospective candidates as radiosensitizers to improve the scheme of radiotherapy.

In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga Costaria costata