English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In our continuing research for bioactive constituents from natural resources, a new methyl threonolactone glucopyranoside ( 1 ), a new methyl threonolactone fructofuranoside ( 2 ), 2 new pyroglutamates ( 3 and 4 ), and 10 known compounds ( 5 - 14 ) were isolated from the whole plant of Spilanthes acmella (L.) L. The structures of these compounds were determined based on various spectroscopic and chemical analyses. All of the isolated compounds were evaluated on bone formation parameters, such as ALP (alkaline phosphatase) and mineralization stimulatory activities of MC3T3-E1 cell lines. The results showed that the new compound, 1,3-butanediol 3-pyroglutamate ( 4 ), 2-deoxy-D-ribono-1,4-lactone ( 6 ), methyl pyroglutamate ( 7 ), ampelopsisionoside ( 10 ), icariside B 1 ( 11 ), and benzyl α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside ( 12 ) stimulated both ALP and mineralization activities.

New Methyl Threonolactones and Pyroglutamates of Spilanthes acmella (L.) L. and Their Bone Formation Activities