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In this study, a family of porphyrins based on 5,10,15,20-Tetrakis(4-ethylphenyl)porphyrin ( 1 , Ph) and six metallo-derivatives (Zn 2+ ( 2 , Ph-Zn), Sn 4+ ( 3 , Ph-Sn), Mn 2+ ( 4 , Ph-Mn), Ni 2+ ( 5 , Ph-Ni), Al 3+ ( 6 , Ph-Al), and V 3+ ( 7 , Ph-V)) were tested as photosensitizers for photodynamic therapy against Leishmania braziliensis and panamensis . The singlet oxygen quantum yield value (Φ Δ ) for ( 1 - 7 ) was measured using 1,3-diphenylisobenzofuran (DPBF) as a singlet oxygen trapping agent and 5,10,15,20-(tetraphenyl)-porphyrin (H2TPP) as a reference standard; besides, parasite viability was estimated by the MTT assay. After metal insertion into the porphyrin core, the Φ Δ increased from 0.76-0.90 and cell viability changed considerably. The Φ Δ and metal type changed the cytotoxic activity. Finally, ( 2 ) showed both the highest Φ Δ (0.90) and the best photodynamic activity against the parasites studied (IC 50 of 1.2 μM).

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In Vitro Anti-Leishmanial Effect of Metallic Meso-Substituted Porphyrin Derivatives against Leishmania braziliensis and Leishmania panamensis Promastigotes Properties