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Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide ( 1 ), and germacrane, 9β-hydroxyparthenolide-9- O -β-D-glucopyranoside ( 2 ), classes have been isolated from the leaves of the Saudi medicinal plant  Anvillea garcinii  along with seven known compounds ( 3 – 9 ). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of  1 – 9  were screened against seven different pathogenic microbes, and compounds  1 – 3  showed a potent antifungal activity.

Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii