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Near-infrared (NIR) fluorescent probes are attractive tools for bioimaging applications because of their low auto-fluorescence interference, minimal damage to living samples, and deep tissue penetration. H 2 S is a gaseous signaling molecule that is involved in redox homeostasis and numerous biological processes in vivo. To this end, we have developed a new red shifted fluorescent probe 1 to detect physiological H 2 S in live cells. The probe 1 is based on a rhodamine derivative as the red shifted fluorophore and the thiolysis of 7-nitro 1,2,3-benzoxadiazole (NBD) amine as the H 2 S receptor. The probe 1 displays fast fluorescent enhancement at 660 nm (about 10-fold turn-ons, k  2 = 29.8 M -1 s -1 ) after reacting with H 2 S in buffer (pH 7.4), and the fluorescence quantum yield of the activated red shifted product can reach 0.29. The probe 1 also exhibits high selectivity and sensitivity towards H 2 S. Moreover, 1 is cell-membrane-permeable and mitochondria-targeting, and can be used for imaging of endogenous H 2 S in living cells. We believe that this red shifted fluorescent probe can be a useful tool for studies of H 2 S biology.

A Fast-Response Red Shifted Fluorescent Probe for Detection of H2S in Living Cells