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Seven known echinulin-related indolediketopiperazine alkaloids ( 1 - 7 ) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus . Using chiral HPLC, the enantiomers of cryptoechinuline B ( 1 ) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B ( 1a ) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B ( 1b ) and neoechinulin C ( 5 ) protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B ( 4 ) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin ( 7 ) showed activity in the 6-OHDA-induced model.

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus